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Peptide library

Tesamorelin

Approved drugGrowth hormone

A stabilized full-length GHRH analog, approved to reduce visceral (deep belly) fat.

FDA-approved (Egrifta) for belly-fat buildup in HIV.

Used for

  • Visceral fat
  • Liver fat
  • GH support, often called the strongest GHRH peptide

How it works

Stimulates natural pulsed GH release; the rise in GH and IGF-1 mobilizes deep abdominal fat in particular.

Half-life: about 30 minutes

What the research shows

  • In a 26-week NEJM trial, daily tesamorelin cut visceral fat (about 15%) and improved triglycerides and cholesterol ratios.
  • In a 6-month JAMA trial it also modestly reduced liver fat.
  • Fat returned after stopping in the extension studies.
Sources
Falutz 2007, N Engl J Med Stanley 2014, JAMA (liver fat)

Dosing

Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.

Work out the units to draw for your vial →

Side effects

  • Joint pain, muscle aches
  • Swelling of hands and feet, numbness
  • Injection-site redness or itching

Cautions

  • Raises GH and IGF-1. Avoid with active cancer or a history of it; can raise blood sugar. Check IGF-1 and fasting glucose on bloodwork.
  • Not for pregnancy.
  • Prohibited in tested sports (WADA).

Storage

Prescribing label

Unmixed or unopened: The 2 mg vial at room temperature (20–25 °C), kept in its box until use to protect it from light.

From the Egrifta SV (Theratechnologies) label.

Stability once mixed

Breaks down fasterFrom the label

Egrifta SV is single-use: mix it, inject, throw the rest away. The multi-dose Egrifta WR is thrown out 7 days after mixing. A compounded multi-dose vial has no data.

Heat, shaking, freezing a mixed vial, light and many needle punctures all speed breakdown. Toss it if it turns cloudy, grows specks or changes color.

Interactions

If you take replacement cortisone or prednisone for an underactive adrenal gland, you may need a higher dose after starting, because GH blocks the enzyme that activates them.

Prescribing labelEgrifta SV label, section 7.2

GH may change how the liver clears drugs processed by CYP450 enzymes (corticosteroids, sex steroids, anticonvulsants, cyclosporine): monitor.

Prescribing labelEgrifta SV label, section 7.1

Not a full list. Tell your doctor and pharmacist everything you take.

More in Growth hormone

SermorelinCJC-1295 without DAC (Mod GRF 1-29)CJC-1295 with DACIpamorelinGHRP-2GHRP-6

Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.