Sermorelin
The first 29 amino acids of growth-hormone-releasing hormone (GHRH): it tells the pituitary to release its own GH.
Was FDA-approved (Geref) for children’s GH deficiency; withdrawn in 2008 for business reasons; now compounded.
Used for
- Adult GH decline (“age management”)
- Sleep, recovery, body composition
How it works
Mimics GHRH in short pulses, so GH still follows the body’s own rhythm and feedback, unlike taking GH itself.
Half-life: about 10–20 minutes
What the research shows
- Approved for GH-deficient children; adult anti-aging use rests on small studies and clinical experience.
- Very short-acting (minutes), so it is given at bedtime to add to the night GH pulse.
Dosing
Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.
Work out the units to draw for your vial →Side effects
- Flushing, injection-site reactions
- Headache
- Water retention
Cautions
- Raises GH and IGF-1. Avoid with active cancer or a history of it; can raise blood sugar. Check IGF-1 and fasting glucose on bloodwork.
- Inject on an empty stomach (about 2 hours after food): carbs and fat blunt the GH pulse.
- Prohibited in tested sports (WADA).
Storage
Unmixed powder: freezer or fridge, away from light.
Once mixed with bacteriostatic water: fridge; the common rule is to use it within 28 days.
There is no label or published stability data for this one, so treat these as habits, not limits.
Stability once mixed
A fragile chain: its methionine oxidizes and its asparagine slowly deamidates, so it breaks down in water faster than most. Community often keeps a mixed vial only 2 to 3 weeks.
Heat, shaking, freezing a mixed vial, light and many needle punctures all speed breakdown. Toss it if it turns cloudy, grows specks or changes color.
More in Growth hormone
Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.