Tesofensine

Used for

• Weight loss
• Appetite and cravings

How it works

Keeps more dopamine, noradrenaline and serotonin active in the brain, which lowers hunger and raises fullness; it quiets appetite-driving neurons in the hypothalamus in rats.

Half-life: about 9 days (steady levels take weeks)

What the research shows

• Phase 2 (24 weeks, 203 people, with diet): weight fell 4.5% on 0.25 mg, 9.2% on 0.5 mg and 10.6% on 1 mg daily, vs 2.0% on placebo.
• Heart rate rose about 7 beats a minute on 0.5 mg; the authors later published a correction for under-reported side effects.
• In people, it lowered hunger and raised fullness in appetite studies.

Dosing

Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.

Side effects

• Dry mouth
• Insomnia (take it in the morning)
• Nausea, constipation or diarrhea
• Faster heart rate, higher blood pressure
• Mood changes, anxiety

Cautions

• Not with MAO inhibitors, SSRIs/SNRIs, stimulants or other serotonin drugs.
• Watch resting heart rate and blood pressure; avoid with heart disease or uncontrolled blood pressure.
• The long half-life means side effects linger for weeks after stopping.
• Research-chemical vials have no quality control: purity, dose and sterility vary. Third-party testing helps but is no guarantee.

Storage

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