Orforglipron
A once-daily pill from Eli Lilly: a small-molecule (non-peptide) GLP-1 agonist that needs no fasting and no water rules.
FDA-approved April 2026 as Foundayo (weight); other uses and countries: check current status.
Used for
- Weight loss
- Type 2 diabetes (studied)
How it works
Acts on the same GLP-1 receptor as semaglutide but is a chemical, not a peptide, so stomach acid does not destroy it and it can be taken with or without food, at any time of day.
Half-life: about 1–2 days (29–49 hours in people with type 2 diabetes after 12 weeks)
What the research shows
- ATTAIN-1 (72 weeks, 3,127 adults with obesity, no diabetes): 6, 12 and 36 mg a day lost 7.5%, 8.4% and 11.2% of body weight vs 2.1% on placebo; 54.6% on 36 mg lost 10% or more. Side effects ended treatment in 5.3–10.3% vs 2.7%.
- ATTAIN-2 (72 weeks, obesity with type 2 diabetes): 5.1%, 7.0% and 9.6% on 6, 12 and 36 mg vs 2.5% on placebo; stopping for side effects 6.1–9.9% vs 4.1%.
- Phase 2 (36 weeks, doses 12–45 mg): 9.4–14.7% weight loss vs 2.3%; stomach side effects, mostly while stepping up, made 10–17% stop.
- ACHIEVE-1 (40 weeks, early type 2 diabetes): HbA1c fell 1.2–1.5 points vs 0.4 on placebo, and weight 4.5–7.6% vs 1.7%.
Dosing
Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.
Work out the units to draw for your vial →Side effects
- Nausea, especially after a dose step
- Constipation or diarrhea
- Reflux, burping
- Lower appetite and thirst: dehydration risk
Cautions
- Not for anyone with a personal or family history of medullary thyroid cancer or MEN2.
- Pancreatitis and gallbladder problems are uncommon but reported; severe belly pain needs urgent care.
- Rapid weight loss costs muscle too: keep protein high and keep lifting.
- Stop before planned surgery or sedation per your doctor (slower stomach emptying).
- Carries the class boxed warning for thyroid C-cell tumors.
Storage
Unmixed or unopened: Tablets at room temperature (20–25 °C; trips to 15–30 °C are fine), in the bottle with its desiccant.
From the Foundayo (Eli Lilly) label.
Interactions
Strong CYP3A4 blockers raise its levels: keep to 9 mg a day or less with them, and avoid those that also block OATP1B (ritonavir is the label’s example). Avoid strong CYP3A4 inducers.
It doubled exposure to simvastatin’s active form: do not go above simvastatin 20 mg a day.
With insulin or a sulfonylurea, consider a lower dose of those drugs when starting (low blood sugar). It also slows stomach emptying, which can change how other pills are absorbed.
Not a full list. Tell your doctor and pharmacist everything you take.
More in Weight & metabolic
Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.