Mazdutide
A once-weekly dual agonist of the GLP-1 and glucagon receptors, from Innovent (China) and Lilly (rest of world).
Approved in China for weight (Xinermei, 2025); investigational elsewhere (Lilly US trials); not FDA-approved.
Used for
- Weight loss
- Type 2 diabetes (studied)
How it works
GLP-1 action lowers appetite; glucagon action adds energy burn and liver fat loss.
What the research shows
- GLORY-1 (China, 48 weeks, 610 adults): 4 mg lost 11.0% and 6 mg 14.0% vs a 0.3% gain on placebo; stopping for side effects 1.5%, 0.5% and 1.0%.
- GLORY-2 (China, 60 weeks, BMI 30 or more): 9 mg lost 16.7% vs 1.5% on placebo. Vomiting 53% vs 1%, nausea 47% vs 3%; 2.9% stopped for side effects.
- US phase 2 (48 weeks, no diabetes): at 32 weeks 3–6 mg lost 7.3%, 10 mg 15.6% and 16 mg 18.1% vs 0.9%. 20% on 16 mg stopped for side effects, mostly stomach-related.
Dosing
Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.
Work out the units to draw for your vial →Side effects
- Nausea, especially after a dose step
- Constipation or diarrhea
- Reflux, burping
- Lower appetite and thirst: dehydration risk
- Vomiting, often more than with other GLP-1s at higher doses
Cautions
- Not for anyone with a personal or family history of medullary thyroid cancer or MEN2.
- Pancreatitis and gallbladder problems are uncommon but reported; severe belly pain needs urgent care.
- Rapid weight loss costs muscle too: keep protein high and keep lifting.
- Stop before planned surgery or sedation per your doctor (slower stomach emptying).
- Outside China it is not approved: long-term safety is still being studied.
- Research-chemical vials have no quality control: purity, dose and sterility vary. Third-party testing helps but is no guarantee.
Storage
Unmixed powder: freezer or fridge, away from light.
Once mixed with bacteriostatic water: fridge; the common rule is to use it within 28 days.
There is no label or published stability data for this one, so treat these as habits, not limits.
One storage test
Fridge (2 °C): 93% left at day 15, 89% at day 61, 38% at day 113.
Room (about 24 °C): 78% at day 7, 71% at day 15, 65% at day 31.
One vial in the fridge and one at room temperature per peptide, mixed with bacteriostatic water (0.9% benzyl alcohol), kept dark, measured by UV light absorbance (a rough proxy, not a purity test). Vendors and lots not named; not peer reviewed. A single test, not a use-by date. Peptide Critic with Analytical Formulations, Apr 2026
More in Weight & metabolic
Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.