LL-37
The only human cathelicidin: an antimicrobial peptide made by skin and immune cells, often raised by vitamin D.
Not approved for human use; sold as a research chemical.
Used for
- Chronic infections and biofilms
- Hard-to-heal wounds
- Immune support
How it works
Punches holes in bacterial membranes, breaks up biofilms and signals immune cells. In excess it drives inflammation (it is high in psoriasis and rosacea).
What the research shows
- A randomized trial of LL-37 applied to venous leg ulcers twice weekly: the two lower strengths healed ulcers several times faster than placebo; the highest did not.
- No trials of injected LL-37.
Dosing
Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.
Work out the units to draw for your vial →Side effects
- Injection-site redness, itching or welts are common
- Flu-like feeling (die-off reactions are claimed)
Cautions
- Can worsen autoimmune or inflammatory skin disease (psoriasis, rosacea, lupus).
- More was worse in the ulcer trial.
- Research-chemical vials have no quality control: purity, dose and sterility vary. Third-party testing helps but is no guarantee.
Storage
Unmixed powder: freezer or fridge, away from light.
Once mixed with bacteriostatic water: fridge; the common rule is to use it within 28 days.
There is no label or published stability data for this one, so treat these as habits, not limits.
More in Healing & recovery
Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.