5-Amino-1MQ

Used for

• Fat loss
• Muscle recovery with aging (mice)
• Metabolic health

How it works

Blocks nicotinamide N-methyltransferase (NNMT), an enzyme that is high in fat tissue. Blocking it raises NAD+ and SAM in fat cells and reduces fat storage.

What the research shows

• Knocking down NNMT in fat and liver protected mice from diet-induced obesity (Kraus 2014).
• In obese mice on a high-fat diet, the inhibitor cut body weight and white fat and lowered cholesterol, with no change in food intake.
• In aged mice, it activated muscle stem cells and improved muscle regeneration after injury.
• A 28-day mouse study found better insulin sensitivity and less fatty liver. No human trials have been published.

Dosing

Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.

Side effects

• Unknown in people; community reports are few (mild stomach upset)

Cautions

• No human safety data: NNMT works in many tissues and the long-term effects of blocking it are unknown.
• Most of the research comes from the group commercializing it.
• Research-chemical vials have no quality control: purity, dose and sterility vary. Third-party testing helps but is no guarantee.

Storage

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