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Peptide library

VIP (vasoactive intestinal peptide)

Limited human dataImmune

Vasoactive intestinal peptide, a gut and nerve hormone that calms inflammation, relaxes blood vessels and airways.

Not approved (IV aviptadil missed its main goal in a COVID trial); nasal VIP is compounded.

Used for

  • Mold-related illness (CIRS), as a nasal spray
  • Inflammatory lung disease (sarcoidosis, studied)
  • Pulmonary hypertension and respiratory failure (studied)

How it works

Acts on VPAC receptors on immune cells, blood vessels and airways: it lowers inflammatory signals like TNF-alpha, raises regulatory T cells and widens vessels and airways.

Half-life: about 1–2 minutes in the blood

What the research shows

  • In 20 people with active sarcoidosis, 4 weeks of inhaled VIP lowered TNF-alpha from lung immune cells and raised regulatory T cells; no placebo group.
  • In critical COVID-19 (IV aviptadil), the main goal was missed, though survival at 60 days was better in secondary analyses.
  • Nasal VIP for CIRS comes from one clinician’s uncontrolled case series, published outside PubMed.
Sources
Prasse 2010, Am J Respir Crit Care Med (sarcoidosis) Youssef 2022, Crit Care Med (COVID-19)

Dosing

Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.

Work out the units to draw for your vial →

Side effects

  • Flushing
  • Low blood pressure, lightheadedness
  • Loose stools
  • Nasal irritation

Cautions

  • Can lower blood pressure: take care if you already run low or take blood pressure drugs.
  • Compounded sprays vary; keep them refrigerated.
  • Research-chemical vials have no quality control: purity, dose and sterility vary. Third-party testing helps but is no guarantee.

Storage

Unmixed powder: freezer or fridge, away from light.

Once mixed with bacteriostatic water: fridge; the common rule is to use it within 28 days.

There is no label or published stability data for this one, so treat these as habits, not limits.

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Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.