Kisspeptin
The hormone at the top of the reproductive axis: it triggers GnRH, then LH and FSH, and so testosterone or ovulation.
Research drug; not approved.
Used for
- Keeping natural testosterone and fertility going (e.g. on TRT)
- IVF egg maturation (research)
- Libido
How it works
Activates GnRH neurons in the hypothalamus, which signal the pituitary to release LH and FSH.
Half-life: about 28 minutes for kisspeptin-54 (IV infusion in men); no figure found for kisspeptin-10
What the research shows
- Kisspeptin-54 raised LH, FSH and testosterone in healthy men.
- In women with hypothalamic amenorrhea, single doses worked but twice-daily dosing for 2 weeks caused the response to fade.
Dosing
Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.
Work out the units to draw for your vial →Side effects
- Few reported in studies; flushing
Cautions
- Continuous exposure can switch the axis off rather than on.
- Research-chemical vials have no quality control: purity, dose and sterility vary. Third-party testing helps but is no guarantee.
Storage
Unmixed powder: freezer or fridge, away from light.
Once mixed with bacteriostatic water: fridge; the common rule is to use it within 28 days.
There is no label or published stability data for this one, so treat these as habits, not limits.
Stability once mixed
A peptide hormone, usually treated as heat-sensitive; there is no stability data. Keep it cold, especially in a hot climate.
Heat, shaking, freezing a mixed vial, light and many needle punctures all speed breakdown. Toss it if it turns cloudy, grows specks or changes color.
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Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.