Enclomiphene
An oral estrogen blocker that raises the body’s own LH, FSH and testosterone while keeping sperm counts, unlike TRT.
Not FDA-approved (the Androxal application was turned down); sold compounded.
Used for
- Low testosterone from a pituitary signal problem (secondary)
- Raising testosterone while keeping fertility
- Coming off TRT
How it works
The active half of clomiphene (Clomid): it blocks estrogen feedback in the brain, so the pituitary sends more LH and FSH and the testes make more testosterone and sperm.
What the research shows
- Phase 2 and 3 trials in overweight men with secondary low T: 12.5–25 mg daily brought testosterone into the normal range and kept sperm counts, while testosterone gel lowered them.
- A 2025 meta-analysis of randomized trials found clomiphene and enclomiphene both raise testosterone in hypogonadal men.
Dosing
Dosing isn’t listed on the public site. In the app, each published option is shown with its source (a drug label, a clinical guideline, a trial or community reports) and can be turned into a protocol you review.
Work out the units to draw for your vial →Side effects
- Headache, hot flashes
- Mood changes
- Rarely: blurred vision or visual spots (stop and see a doctor)
Cautions
- Works only if the testes can respond: not for primary testicular failure.
- Estradiol rises with testosterone: check both on bloodwork.
- Visual disturbances are a stop sign.
- Prohibited in tested sports (WADA).
Storage
Unmixed powder: freezer or fridge, away from light.
Once mixed with bacteriostatic water: fridge; the common rule is to use it within 28 days.
There is no label or published stability data for this one, so treat these as habits, not limits.
Reference only, not medical advice. Written for this app from the cited research. Doses marked community-reported are not from trials.